Dissertations@Portsmouth - Details for item no. 14193

Dolphin, Billie (2021) The role of variant histones in cellular reprogramming. (unpublished MPhil dissertation), University of Portsmouth, Portsmouth

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Abstract

Regenerative medicine is the next evolution of 21st century healthcare, derived from the 3 fields of tissue engineering, biochemistry, biology, applied engineering and others, creating 4 the first interdisciplinary field that can utilize and bring together numerous areas of science. 5 This field will lead to the creation of biological tissues and organs that can replace or 6 regenerate the patient’s cell type that is in need of repair, devoid of ethical constraints. 7 Regenerative medicine is regarded as a solution to current healthcare limitations such as 8 immunological rejection from donated organs and the global struggle to meet the 9 increasing demand of donor organs. Cellular Reprogramming is the conversion of one 10 specific cell type to another (trans differentiation) which despite major advances in this field 11 over the past 50 years, researchers still know very little about the underlying science. In 12 order to build complex tissues and organs, we must first understand the fundamental 13 network of biological interactions between these tissues.

Course: Master of Philosophy - MPhil

Date Deposited: 2023-09-13

URI/permalink: https://library.port.ac.uk/dissert/dis14193.html